Yes, PILOTS is a Scrabble word!

Letter values in Scrabble US: P 3, I 1, L 1, O 1, T 1, S 1.

Is it a valid word?

PILOTS is a valid word in the official Scrabble dictionary (US), the UK Scrabble Dictionary and Words with Friends (ENABLE).

someone who is licensed to operate an aircraft in flight
a person qualified to guide ships through difficult waters going into or out of a harbor
a program exemplifying a contemplated series; intended to attract sponsors
something that serves as a model or a basis for making copies
small auxiliary gas burner that provides a flame to ignite a larger gas burner
an inclined metal frame at the front of a locomotive to clear the track

operate an airplane
act as the navigator in a car, plane, or vessel and plan, direct, plot the path and position of the conveyance

Also: airplane pilot, pilot program, pilot film, pilot burner, pilot light.