Yes, oppose is a Scrabble word!
...and is worth 10 points in Scrabble, and 12 points in Words with Friends
oppose
Verb
1. Be against; express opposition to
2. Fight against or resist strongly
3. Contrast with equal weight or force
4. Set into opposition or rivalry
5. Act against or in opposition to
6. Be resistant to
What Scrabble words can I make with the letters in oppose?
5 Letter Words
4 Letter Words
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3 Letter Words
2 Letter Words