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Yes, refrain is a Scrabble word!
...and is worth 10 points in Scrabble, and 11 points in Words with Friends
1. Resist doing something
2. Choose not to consume
1. The part of a song where a soloist is joined by a group of singers
What Scrabble words can I make with the letters in refrain?
6 Letter Words
5 Letter Words
4 Letter Words
3 Letter Words
2 Letter Words