Yes, TALKERS is a Scrabble word!

Letter values in Scrabble US: T 1, A 1, L 1, K 5, E 1, R 1, S 1.

Is it a valid word?

TALKERS is a valid word in the official Scrabble dictionary (US), the UK Scrabble Dictionary and Words with Friends (ENABLE).

someone who expresses in language; someone who talks (especially someone who delivers a public speech or someone especially garrulous)

Not playable in Scrabble US: VERBALISER.