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Yes, pest is a Scrabble word!
...and is worth 6 points in Scrabble, and 7 points in Words with Friends
1. A serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of a flea that has bitten an infected animal
2. Any epidemic disease with a high death rate
3. A persistently annoying person
4. Any unwanted and destructive insect or other animal that attacks food or crops or livestock etc.
What Scrabble words can I make with the letters in pest?
4 Letter Words
3 Letter Words
2 Letter Words