Yes, knife is a Scrabble word!
...and is worth 12 points in Scrabble, and 13 points in Words with Friends
knife
Verb
1. Use a knife on
Noun
1. Edge tool used as a cutting instrument; has a pointed blade with a sharp edge and a handle
2. A weapon with a handle and blade with a sharp point
3. Any long thin projection that is transient
What Scrabble words can I make with the letters in knife?
4 Letter Words
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3 Letter Words
2 Letter Words