Yes, SPHERES is a Scrabble word!

Letter values in Scrabble US: S 1, P 3, H 4, E 1, R 1, E 1, S 1.

Is it a valid word?

SPHERES is a valid word in the official Scrabble dictionary (US), the UK Scrabble Dictionary and Words with Friends (ENABLE).

a particular environment or walk of life
any spherically shaped artifact
the geographical area in which one nation is very influential
a particular aspect of life or activity
a solid figure bounded by a spherical surface (including the space it encloses)
a three-dimensional closed surface such that every point on the surface is equidistant from the center
the apparent surface of the imaginary sphere on which celestial bodies appear to be projected

Also: sphere of influence, celestial sphere, vault of heaven.