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Yes, expire is a Scrabble word!
...and is worth 15 points in Scrabble, and 16 points in Words with Friends
1. Lose validity
2. Pass from physical life and lose all bodily attributes and functions necessary to sustain life
3. Expel air
What Scrabble words can I make with the letters in expire?
4 Letter Words
3 Letter Words
2 Letter Words