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Yes, demesne is a Scrabble word!
...and is worth 10 points in Scrabble, and 12 points in Words with Friends
1. Extensive landed property (especially in the country) retained by the owner for his own use
2. Territory over which rule or control is exercised
What Scrabble words can I make with the letters in demesne?
7 Letter Words
6 Letter Words
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2 Letter Words