Yes, brain is a Scrabble word!
...and is worth 7 points in Scrabble, and 9 points in Words with Friends
brain
Verb
1. Hit on the head
2. Kill by smashing someone's skull
Noun
1. That part of the central nervous system that includes all the higher nervous centers; enclosed within the skull; continuous with the spinal cord
2. Mental ability
3. That which is responsible for one's thoughts and feelings; the seat of the faculty of reason
4. Someone who has exceptional intellectual ability and originality
5. The brain of certain animals used as meat
What Scrabble words can I make with the letters in brain?
5 Letter Words
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