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Yes, anti is a Scrabble word!
...and is worth 4 points in Scrabble, and 5 points in Words with Friends
1. Not in favor of (an action or proposal etc.)
1. A person who is opposed (to an action or policy or practice etc.)
What Scrabble words can I make with the letters in anti?
4 Letter Words
3 Letter Words
2 Letter Words