Yes, SHAKEUPS is a Scrabble word!

Letter values in Scrabble US: S 1, H 4, A 1, K 5, E 1, U 1, P 3, S 1.

Is it a valid word?

SHAKEUPS is a valid word in the official Scrabble dictionary (US), the UK Scrabble Dictionary and Words with Friends (ENABLE).

the imposition of a new organization; organizing differently (often involving extensive and drastic changes)

Also: shake-up.

Not playable in Scrabble US: REORGANISATION.