Yes, PLAYERS is a Scrabble word!

Letter values in Scrabble US: P 3, L 1, A 1, Y 4, E 1, R 1, S 1.

Is it a valid word?

PLAYERS is a valid word in the official Scrabble dictionary (US), the UK Scrabble Dictionary and Words with Friends (ENABLE).

a person who participates in or is skilled at some game
someone who plays a musical instrument (as a profession)
a theatrical performer
a person who pursues a number of different social and sexual partners simultaneously
an important participant (as in a business deal)

Also: role player.

Not playable in Scrabble US: HISTRION.