Yes, setose is a Scrabble word!
...and is worth 6 points in Scrabble, and 6 points in Words with Friends
setose
Adjective
1. Having or covered with protective barbs or quills or spines or thorns or setae etc.
What Scrabble words can I make with the letters in setose?
4 Letter Words
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3 Letter Words
2 Letter Words