Yes, EXPEDIENCE is a Scrabble word!

Letter values in Scrabble US: E 1, X 8, P 3, E 1, D 2, I 1, E 1, N 1, C 3, E 1.

Is it a valid word?

EXPEDIENCE is a valid word in the official Scrabble dictionary (US), the UK Scrabble Dictionary and Words with Friends (ENABLE).

the quality of being suited to the end in view
taking advantage of opportunities without regard for the consequences for others

Also: self-interest, self-seeking.