Yes, CYCLOPES is a Scrabble word!

Letter values in Scrabble US: C 3, Y 4, C 3, L 1, O 1, P 3, E 1, S 1.

Is it a valid word?

CYCLOPES is a valid word in the official Scrabble dictionary (US) and the UK Scrabble Dictionary, but not in Words with Friends (ENABLE).

only the silky anteater
(Greek mythology) one of a race of giants having a single eye in the middle of their forehead
minute free-swimming freshwater copepod having a large median eye and pear-shaped body and long antennae used in swimming; important in some food chains and as intermediate hosts of parasitic worms that affect man e.g. Guinea worms

Also: genus cyclopes, water flea.