Yes, CHOLER is a Scrabble word!

Letter values in Scrabble US: C 3, H 4, O 1, L 1, E 1, R 1.

Is it a valid word?

CHOLER is a valid word in the official Scrabble dictionary (US), the UK Scrabble Dictionary and Words with Friends (ENABLE).

an irritable petulant feeling
a strong emotion; a feeling that is oriented toward some real or supposed grievance
a humor that was once believed to be secreted by the liver and to cause irritability and anger

Also: yellow bile.