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Yes, SIGNIFICANTLY is a Scrabble word! Letter values in Scrabble US: S 1, I 1, G 2, N 1, I 1, F 4, I 1, C 3, A 1, N 1, T 1, L 1, Y 4. S 1 · I 1 · G 2 · N 1 · I 1 · F 4 · I 1 · C 3 · A 1 · N 1 · T 1 · L 1 · Y 4
Is it a valid word? Scrabble US: valid, 22 points. Scrabble US Your dictionary · Change (go to the dictionary switch) Valid · 22 points Scrabble UK: valid, 22 points. Make Scrabble UK your dictionary. Scrabble UK Your dictionary · Change Valid · 22 points Words with Friends: valid, 26 points. Make Words with Friends your dictionary. Words with Friends Your dictionary · Change Valid · 26 points
Find words from your rack About SIGNIFICANTLY SIGNIFICANTLY is a valid word in the official Scrabble dictionary (US), the UK Scrabble Dictionary and Words with Friends (ENABLE).
Definitions adverb in a statistically significant way in a significant manner in an important way or to an important degree