Yes, MANIPULATION is a Scrabble word!

Letter values in Scrabble US: M 3, A 1, N 1, I 1, P 3, U 1, L 1, A 1, T 1, I 1, O 1, N 1.

Is it a valid word?

MANIPULATION is a valid word in the official Scrabble dictionary (US), the UK Scrabble Dictionary and Words with Friends (ENABLE).

exerting shrewd or devious influence especially for one's own advantage
the action of touching with the hands (or the skillful use of the hands) or by the use of mechanical means