Yes, HUSTLES is a Scrabble word!

Letter values in Scrabble US: H 4, U 1, S 1, T 1, L 1, E 1, S 1.

Is it a valid word?

HUSTLES is a valid word in the official Scrabble dictionary (US), the UK Scrabble Dictionary and Words with Friends (ENABLE).

a swindle in which you cheat at gambling or persuade a person to buy worthless property
a rapid active commotion

cause to move furtively and hurriedly
move or cause to move energetically or busily
sell something to or obtain something from by energetic and especially underhanded activity
get by trying hard
pressure or urge someone into an action

Also: bunco game, bunko game, confidence trick, confidence game, con game, bustle about.