Yes, CHAMELEONS is a Scrabble word!

Letter values in Scrabble US: C 3, H 4, A 1, M 3, E 1, L 1, E 1, O 1, N 1, S 1.

Is it a valid word?

CHAMELEONS is a valid word in the official Scrabble dictionary (US), the UK Scrabble Dictionary and Words with Friends (ENABLE).

a changeable or inconstant person
a faint constellation in the polar region of the southern hemisphere near Apus and Mensa
lizard of Africa and Madagascar able to change skin color and having a projectile tongue

Not playable in Scrabble US: CHAMAELEON.