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Yes, guile is a Scrabble word!
...and is worth 6 points in Scrabble, and 9 points in Words with Friends
1. Shrewdness as demonstrated by being skilled in deception
2. The quality of being crafty
3. The use of tricks to deceive someone (usually to extract money from them)
What Scrabble words can I make with the letters in guile?
4 Letter Words
3 Letter Words
2 Letter Words