Yes, FRUSTRATION is a Scrabble word!

Letter values in Scrabble US: F 4, R 1, U 1, S 1, T 1, R 1, A 1, T 1, I 1, O 1, N 1.

Is it a valid word?

FRUSTRATION is a valid word in the official Scrabble dictionary (US), the UK Scrabble Dictionary and Words with Friends (ENABLE).

the feeling that accompanies an experience of being thwarted in attaining your goals
an act of hindering someone's plans or efforts
a feeling of annoyance at being hindered or criticized